Sacubitril/Valsartan partially alleviates myocardial infarction injury by activating the FGF21 signaling pathway via PPARs
Wei W, Xu G, Gao J, Wang G, Wang Y, Li C, Zheng J, Lu H, Lu Y, Wang K, Xu H, Wang C, Pan X. Sacubitril/Valsartan partially alleviates myocardial infarction injury by activating the FGF21 signaling pathway via PPARs. Cardiovasc Diabetol. 2025 Feb 22;24(1):89. doi: 10.1186/s12933-025-02627-6.
小鼠
心血管疾病
2025
N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis
Liu ZY, Lin LC, Liu ZY, Song K, Tu B, Sun H, Zhou Y, Mao S, Zhang Y, Li R, Yang JJ, Zhao JY, Tao H. N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis. Cardiovasc Diabetol. 2024 Sep 28;23(1):347. doi: 10.1186/s12933-024-02444-3.
小鼠
心血管疾病
2024
Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis
Zhang Y, Du W, Kong T, Hua T, Ma H, Hu Y, Pan S, Ling B, Yang M, Cheng C. Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis. Cell Death Discov. 2025 Feb 21;11(1):71. doi: 10.1038/s41420-025-02356-5.
大鼠
腫瘤疾病
2025
Key subdomains of mesencephalic astrocyte-derived neurotrophic factor attenuate myocardial ischemia/reperfusion injury by JAK1/STAT1/NF-κB signaling pathway
Dong H, Jia W, Wang C, Teng D, Xu B, Ding X, Yang J, Zhong L, Gong L. Key subdomains of mesencephalic astrocyte-derived neurotrophic factor attenuate myocardial ischemia/reperfusion injury by JAK1/STAT1/NF-κB signaling pathway. Mol Med. 2024 Sep 6;30(1):139. doi: 10.1186/s10020-024-00916-6.
小鼠
心血管疾病
2024
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways
Li Z, Ran Q, Qu C, Hu S, Cui S, Zhou Y, Shen B, Yang B. Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways. Biol Direct. 2025 Feb 25;20(1):23. doi: 10.1186/s13062-025-00617-y.
小鼠
心血管疾病
2025
Curcumin attenuates myocardial ischemia-reperfusion-induced autophagy-dependent ferroptosis via Sirt1/AKT/FoxO3a signaling
Zhao ST, Qiu ZC, Xu ZQ, Tao ED, Qiu RB, Peng HZ, Zhou LF, Zeng RY, Lai SQ, Wan L. Curcumin attenuates myocardial ischemia?reperfusion?induced autophagy?dependent ferroptosis via Sirt1/AKT/FoxO3a signaling. Int J Mol Med. 2025 Mar;55(3):51. doi: 10.3892/ijmm.2025.5492. Epub 2025 Jan 24. PMID: 39930816; PMCID: PMC11781526.
小鼠
心血管疾病
2025